Research lab
Biomedical research institute affiliated with MIT and Harvard, known for genome sequencing, CRISPR gene-editing research, and datasets like MitoCarta.
Broad and MIT researchers watched single receptors on live cells for over 16 minutes and found that normal HER3 forms stable pairs. Cancer-linked HER3 mutations loosened those pairs, and the idea that this frees HER3 to drive signaling is still the team's working model.
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MitoCarta mapped the genome and mitochondrial proteins of Acanthamoeba, the eye-infecting amoeba, across two of nine new papers. Its current drugs are untargeted and toxic, its lead author says, and a precise protein map is the first step toward better ones.
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Broad Institute-led researchers have catalogued mitochondrial proteins in one plant and five human parasites across nine papers in Cell and related journals. Parasite proteins that human mitochondria lack give neglected tropical disease programs a first list of candidate drug targets to test.
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Vijay Sankaran's team pooled genetic data from more than 28,000 people and found a BACH2-NRF2 axis that switches on fetal hemoglobin without going through BCL11A. Blocking it in cells raised fetal hemoglobin, pointing drug programs at a target beyond Casgevy's gene edit.
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Microsoft says its Quine system narrowed thousands of compounds to a pancreatic cancer shortlist in one weekend. For research-AI teams, the part to study is the harness that sends lab results back into the next question, and nobody has yet measured its value across cycles.
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AlphaGenome Atlas answers every possible one-letter question in the human genome in advance, roughly a petabyte of predictions. Noncommercial access opened Tuesday, commercial use waits on Google Cloud, and the launch write-up carries no accuracy number.
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Anthropic says its agents worked autonomously and that the same triage would take an expert scientist weeks or months. The company supplies that comparison itself, the preprint is unreviewed, and the enzyme system's function is unknown.
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Anthropic's new in-house molecular biology lab says a 21.5 hour agent run turned a 1.9 billion cluster database into 19 reports for humans to read, and one of them described a repeat array nobody had recorded.
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The company's new life sciences group says agents working from a single prompt flagged an enzyme system with CRISPR-like DNA repeats, and its scientists are still running experiments to find out what the system actually does.
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The MIT group measured skin and lung cells from 2-month-old and 26-month-old mice both ways at once, using the destructive sequencing read to label the optical one. Human tissue, the authors say, is next.
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Academics get all 9 billion single-base predictions through a browser at no cost, while commercial users wait on a Google Cloud licence whose terms DeepMind has not published, including for its own sister company.
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AlphaGenome Atlas scores every possible single-letter change in the human genome and hands the result to anyone with a browser, which moves the scarce input from computing a prediction to confirming one. Price and drug-developer partnerships go unmentioned in the release.
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AlphaGenome Atlas turns per-variant inference into a table lookup and adds a ranking score, which changes what a genomics budget buys this quarter well before it changes what a clinic can act on.
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A repurposed retroviral shell protein lets a culture report its own gene activity again and again instead of once, so a single well becomes its own before-and-after control, at population-average resolution.
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The Stanford tool is less than half the size of comparable CRISPR activators by amino acid count, which is what lets one virus carry it along with the guides that aim it, and in injured mouse retinas it preserved partial vision.
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