Research lab
Medical school and research arm of Mount Sinai Health System in New York City, spanning neuroscience, genetics, and clinical research.
Laurel Morris's team at Mount Sinai reported that one neurofeedback session improved mood in people with depression more than sham feedback did. It lasted into the next day, was gone at one week, and came without a significant difference in activity in the targeted region.
Reality
Sami Kanaan's team at the Fred Hutchinson Cancer Center detected maternal cells in 26 of 37 children's brain samples, averaging 2.2 per 100,000 cells. A mosaic brain is a fair inference, but whether the cells affect function or disease is a separate question.
Reality
Joel Blanchard's Mount Sinai team reports in Cell that APOE4 pushes brain vessel cells toward a scar-producing state in lab-grown tissue. In people the evidence is a comparison of cell counts, so the link to amyloid rests on models.
Reality
Nirao Shah's Stanford team found that female mice need a neuron type making up under 0.001 per cent of brain cells to sustain a pregnancy. Any role in unexplained miscarriage or failed IVF in women is still a hypothesis, because the deletion experiment can only be done in animals.
Reality
Mount Sinai reports in Nature that blocking an amygdala-to-hypothalamus pathway in mice kept prior stress from amplifying later threat responses. Trauma-sensitization research now has one circuit to test. So far, every causal test of it has been in mice.
Reality
Mount Sinai researchers report APOE4 turns brain pericytes into scar-making cells, and blocking TGF-beta reversed the change in aged mice. That gives drug developers a vascular target in carriers of the strongest known genetic risk factor for Alzheimer's.
Reality
Mount Sinai's 30-person pilot found an at-home magnetic headset beat a sham on long COVID cognition, with gains holding a month after treatment ended. Only 10 people were in the sham arm, so the result argues for a larger trial before anyone calls the headset a treatment.
Reality
Mount Sinai researchers estimate that Phelan-McDermid syndrome affects about 1 in 7,300 people, more than 45,000 of them in the US. The figure is modelled from 180,000 tested autistic people, and the authors say the missing diagnoses matter as targeted trials begin.
Reality
Mount Sinai researchers report that APOE4 turns vessel-support cells into scar-forming ones, and that blocking TGF-beta reversed it in aged mice. Both reversals so far are in aged mice and in stem-cell-derived human tissue.
Reality
Mount Sinai and CPTAC collaborators measured DNA, RNA, proteins and protein modifications in tumors from patients aged 83 days to 40 years. Molecular profiles and survival split adolescents and young adults into two groups.
Reality
Researchers at Mount Sinai counted drug trials collecting wearable data on ClinicalTrials.gov, and ten years of growth turned out to be gradual, with the researchers quoted by Nature split on whether sensor capability or validation work is the holdup.
Reality
Mount Sinai's Nature paper argues that neurons trade repair for stress management after injury. Deleting or drugging the aryl hydrocarbon receptor tipped that balance back toward rebuilding, in mice.
Reality
A matched comparison of 471 burn patients found shorter stays and half the complication rate with intact cod skin. The trial now running does not test that comparison.
Reality
Systemic TIMP2 injections moved aged mouse microglia out of pro-inflammatory states and restored debris clearance. The press material omits dose, journal, and any cognitive readout.
Reality