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Human tissue alternatives to animal studies

Lab-grown human tissue models—organoids, spheroids, cell cultures—used to complement or replace animal testing in biomedical research.

Current stories

scienceOne report1 publisher

Animal-free test methods still have to prove themselves against the animal experiments they would replace

Harvard's lung-on-a-chip has nearly 5,400 citations since 2010, but most non-animal test methods have yet to be rigorously tested, IEEE Spectrum reports. Validation means head-to-head runs against animal experiments, so animal data remains the yardstick for now.

Reality

Evidence50
Adoption20
Hype gap+15
Incentives45
Confidence55
scienceOne report1 publisher

CNPEM built a microfluidic chip that gives the spheroid back after the assay

The Brazilian group's platform grows 3D cell models under continuous flow and opens afterward so the tissue can be recovered intact, with plans to offer it to outside labs as shared infrastructure early next year.

Publishers:phys.org

Reality

Evidence55
Adoption
Not scored
Hype gap+28
Incentives60
Confidence52
scienceOne report1 publisher

Seven years in a dish: brain organoids keep their own clock, and it can be pushed

The oldest human brain organoids on record matured for seven years with no body attached, and one experiment showed their developmental schedule can be pushed forward.

Publishers:phys.org

Reality

Evidence66
Adoption
Not scored
Hype gap+12
Incentives48
Confidence58