Topic
The most aggressive form of diffuse glioma, a primary brain tumour marked by short median survival and by tumour cells that resist radiation and chemotherapy.
University of Sydney researchers report that the cancer drug zavondemstat works mainly by blocking the enzyme DHODH, not the KDM4 proteins it was built to hit. The experiments were done in glioblastoma cells, and the drug is already in human trials.
Reality
The WashU group reports in Nature that the structures activate in mice before distant lymph nodes get the signal, and that a gel of three immune proteins placed under the scalp boosted the antitumor response.
Reality
The MIT Media Lab's injectable devices convert an external magnetic field into an electric field at the tumor itself, which killed chemoresistant patient cells in a dish and slowed the same tumors in mouse brains.
Reality
Researchers report in Nature that mouse skull bone marrow holds germinal-centre-like lymphoid structures that respond to CNS antigens and help drive anti-tumour immunity.
Perspective Coverage
3 publishersReality
Ohio State reports that glioblastoma suppresses the enzyme PP2A using three of its own proteins, and that knocking those down in lab and animal models killed more cells and left the survivors easier to irradiate. No patients have been treated.
Reality