Topic

Neuroinflammation

Immune activation in the brain and spinal cord, driven by glial cells and signaling molecules, implicated in neurodegenerative disease and age-related decline.

Current stories

scienceConfirmed2 publishers

Birmingham team halts inflammatory signalling in surgical human brain slices by blocking P2X7

University of Birmingham researchers report in Brain that blocking the P2X7 receptor halted inflammatory cytokine release in living human brain slices. That makes existing P2X7 drugs fair candidates for brain-disease trials, though the evidence so far comes from tissue kept alive outside the body.

Publishers:genengnews.com neurosciencenews.com sciencedaily.com

Perspective Coverage

3 publishers

Builder: Builder 50%
Operator: Operator 23%
Investor: Investor 27%

Reality

Evidence55
Adoption: Not scored
Hype gap+40
Incentives40
Confidence60

scienceOne report1 publisher

One flu or COVID infection sped motor decline in ALS animal models through lasting spinal inflammation

McMaster University researchers report that one flu or COVID infection sped motor decline in animal models of ALS. The work points to respiratory infection as an accelerant of the disease that treatment can blunt, but so far every result comes from animals.

Publishers:neurosciencenews.com

Reality

Evidence42
Adoption: Not scored
Hype gap+35
Incentives55
Confidence40

scienceOne report1 publisher

Catestatin, a chromogranin A fragment, reduced both amyloid and tau in mouse models

UC San Diego researchers report that catestatin, an endogenous piece of chromogranin A, lowered amyloid, tau and neuroinflammation in mice while improving memory and motor scores. Which of those effects drives the others is still open.

Publishers:neurosciencenews.com

Reality

Evidence32
Adoption: Not scored
Hype gap+38
Incentives68
Confidence45

scienceOne report1 publisher

Restoring Menin in old mice improved skin, bone and cognition within 30 days

Lige Leng's team at Xiamen University deleted the protein in young mice and delivered it back into 20-month-old ones, a pairing that separates a driver of aging from a marker. The D-serine arm covered cognition only.

Publishers:sciencedaily.com

Reality

Evidence55
Adoption: Not scored
Hype gap+18
Incentives40
Confidence58

scienceOne report1 publisher

Mount Sinai puts a youth protein on aging microglia, and the mice answer

Systemic TIMP2 injections moved aged mouse microglia out of pro-inflammatory states and restored debris clearance. The press material omits dose, journal, and any cognitive readout.

Publishers:neurosciencenews.com

Reality

Evidence52
Adoption: Not scored
Hype gap+38
Incentives66
Confidence44