Topic
Laboratory and animal studies conducted before human trials, used to test safety and efficacy of a candidate therapy or device prior to clinical testing.
Researchers at The Ottawa Hospital reversed autism-linked behaviours in 16p11.2 mice by restoring blood flow in brain vessels that held half the normal ATP. The drug that did it is already approved for people in Japan and South Korea, though for dry eye, not autism.
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University of Barcelona researchers found that tirzepatide activated calorie-burning brown fat in obese mice eating the same amount as untreated controls. The result points to an effect on metabolism beyond appetite that has not yet been tested in humans.
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Formulators expected fluid lipid membranes to leak fastest. With the water-soluble neurotoxin tetrodotoxin inside, the most unsaturated liposomes released it slowest and numbed a rat's leg for weeks.
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APR says the radiofrequency microporation inside its Medicube Age-R Booster Pro X2 raised minoxidil deposition in animal skin, and it wants that delivery route to become a scalp and hair loss platform. The clinical work is still to come.
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The MIT Media Lab's injectable devices convert an external magnetic field into an electric field at the tumor itself, which killed chemoresistant patient cells in a dish and slowed the same tumors in mouse brains.
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