Houston-based academic medical center and research institution training physicians and conducting biomedical research.
NIH's SMaHT Network has published its first benchmarking study in Cell, calibrating sequencing methods for rare somatic mutations. The researchers say the methods are more sensitive and specific than before, and call the work foundational for disease studies beyond cancer.
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Neurons in the hippocampus of anesthetized epilepsy-surgery patients carried information about word types and upcoming words, Baylor researchers report in Nature. The result bears on whether language processing needs consciousness, though the recordings show what neurons encode and leave comprehension open.
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Baylor researchers screened MECP2 regulatory regions in stem-cell-derived neurons and found one inherited variant that cut expression about 30%. The authors suggest it may explain part of autism's male skew and offer the assay as a template for other X-linked genes.
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A Baylor College of Medicine team used a structure-prediction workflow called GluePlex to find where a molecular glue grips the protein VAV1 before any experiment showed it. A separate group later reached the same conclusion in the lab.
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Baylor researchers tied reduced BRSK1 function to a neurodevelopmental disorder in 10 people from seven families after an AI tool flagged the gene. The variant was already in sequencing data that standard analysis had left unsolved, so the gain came from reading that data again, and fruit-fly experiments supplied the functional evidence.
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Baylor researchers report in Nature Cancer that stroke speeds glioma growth in mouse and human models by remodeling two brain-cell populations. Reversing the change in those cells slowed the tumors and pointed to SLC4A4 and CCL2 as targets.
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In mice, pregnancy turns up an SK3 potassium channel that quiets dorsal raphe serotonin neurons and raises the pull of palatable food. The team tested the channel in both directions before tracing its path to the reward system.
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A 3-year-old whose liver cancer outlasted surgery and three lines of chemotherapy has been in complete remission for a year after CAR T cells given entirely in the outpatient setting, Baylor doctors report.
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Risk this large has been hard to measure because the variant is so rare, and the estimate exists because a consumer genetics cohort held 641 carriers when two major biobanks held 21. A CT screening trial is now running.
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The Aug. 10 order also cuts the routine childhood list from 18 vaccines to 11 on the argument that the United States is out of step with Europe, and the pediatricians who have read it say no new safety or efficacy data came with it.
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Low-intensity sound wave treatment for erectile dysfunction is sold session by session in cash-pay clinics. Cochrane reviewed 21 studies and found the results too variable to trust.
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