The U.S. National Cancer Institute is a federal agency, part of the NIH, that funds and conducts cancer research, treatment, and prevention programs.
The DNA damage behind skin cancer has a settled mechanism and a dose-response. The benefits attributed to sunlight rest on observational studies that vitamin D supplement trials have not confirmed, and guidance is beginning to split.
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Duke researchers imaged whole mouse ovaries and report in eLife that the rete ovarii keeps three distinct regions into adulthood, with cell-secreted proteins in its tubes and nerve fibers connected to one of them.
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Risk this large has been hard to measure because the variant is so rare, and the estimate exists because a consumer genetics cohort held 641 carriers when two major biobanks held 21. A CT screening trial is now running.
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Mount Sinai and CPTAC collaborators measured DNA, RNA, proteins and protein modifications in tumors from patients aged 83 days to 40 years. Molecular profiles and survival split adolescents and young adults into two groups.
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A Nature Medicine study from Washington University reports that more recent generations look biologically older than earlier ones did at the same age, and that a larger gap goes with higher risk of early-onset cancer.
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Ohio State reports that glioblastoma suppresses the enzyme PP2A using three of its own proteins, and that knocking those down in lab and animal models killed more cells and left the survivors easier to irradiate. No patients have been treated.
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The National Cancer Institute treats financial toxicity as a clinical variable. The studies advisors cite claim it moves survival. That claim is what turns the few weeks before treatment starts into billable ground.
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Cervical cancer is falling where vaccination took hold. HPV throat and mouth cancers tripled in US data to 2004 and again in Danish data to 2017, mostly in men, with no screening test.
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Johns Hopkins and NIH researchers report faster, cleaner translation from an alternative mRNA modification than from the chemistry used in COVID-19 mRNA vaccines. Dose economics is the open question.
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